Development of platform to reconstruc inter-organoid connectivity for drug screening and modeling early stages of Parkinson’s disease


  • Reconstruct unidirectional connectivity between brain region-specific organoids (Development of organoid-on-a chip/plate capable of reconstructing nigro (midbrain)-striatal circuit as a dopaminergic pathway)
  • Construct brain region-specific and early Parkinson’s disease-modeling organoids
  • Develop 3D MEA for measurements of electrophysiological signals between organoids
  • Develop highly sensitive sensor for monitoring spatiotemporal secretion and transmission of dopamine
  • Develop delivery system of genes and drug candidates for constructing disease model organoids
  • Investigate organoids’ physiological changes by mechanism of ion channel molecules and neural stem cells’ mechanobiology