Purpose
- Reconstruct unidirectional connectivity between brain region-specific organoids (Development of organoid-on-a chip/plate capable of reconstructing nigro (midbrain)-striatal circuit as a dopaminergic pathway)
- Construct brain region-specific and early Parkinson’s disease-modeling organoids
- Develop 3D MEA for measurements of electrophysiological signals between organoids
- Develop highly sensitive sensor for monitoring spatiotemporal secretion and transmission of dopamine
- Develop delivery system of genes and drug candidates for constructing disease model organoids
- Investigate organoids’ physiological changes by mechanism of ion channel molecules and neural stem cells’ mechanobiology
