최낙원, Nakwon Choi

Principal Researcher

OFFICE

L7325A, +82-958-6742

LAB

L7325, L7336, L7226

EDUCATION
Ph.D. Chemical Engineering, Cornell University (2010)
M.S. Chemical Engineering, Cornell University (2008)
B.S. Chemical Engineering, Seoul National University (2004)

RESEARCH CAREER & ACTIVITIES
  • Principal Research Scientist, Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST) (2017-Present)
  • Senior Research Scientist, Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST) (2012-2016)
  • Associate Professor, Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology (UST) (2012-Present)
  • Adjunct Professor, Department of Neurology, College of Medicine, Hanyang University (2015-2017)
  • Presidential Postdoctoral Fellow, Hits Discovery Group (HDG), Center for Proteomic Chemistry (CPC), Lead Finding Platform (LFP), Novartis Institutes for Biomedical Research (NIBR) (2010-2011)
  • Research Affiliate (Postdoctoral Fellow), Department of Chemical Engineering, Massachusetts Institute of Technology (MIT) (2010-2011)
  • Research Assistant/Teaching Assistant, School of Chemical and Biomolecular Engineering, Cornell University (2004-2009)
  • Commissioned Research Scientist, Korea Institute of Science and Technology (KIST)
RESEARCH INTERESTS
  • Brain/neural tissue engineering: development of brain-on-chips (physiologically relevant 3D culture platforms) such as neural circuit-on-a chip, neurovascular unit (NVU)-on-a chip, and blood-brain barrier (BBB)-on-a chip
  • Brain neural tissue engineering: development of disease models in vitro based on brain-on- chips such as brain tumor and Alzheimer’s disease
  • Hydrogel-based in vitro diagnostics and prognosis: development of hydrogel-based bioassays for multiplex detection of DNAs (qPCR), miRNAs, and proteins associated with various diseases including neurodegenerative diseases
HIGHLIGHT
  • Choi W†, Yeom SY†, Kim J, Jung S, Jung S, Shim TS, Kim SK, Kang JY, Lee SH, Cho I-J, Choi J*, Choi N*, Hydrogel micropost-based qPCR for multiplex detection of miRNAs associated with Alzheimer's disease, Biosensors and Bioelectronics 101, 235-244 (2018)
  • Kim SH†, Im S-K†, Oh S-J†, Jeong S, Yoon E-S, Lee CJ, Choi N*, Hur E-M*, Anisotropically organized three- dimensional culture platform for reconstruction of a hippocampal neural network, Nature Communications 14346 (2017); highlighted in Nature Reviews Materials
  • Kim J, An H, Seo Y, Jung Y, Lee JS, Choi N*, Bong KW*, Flow lithography in ultraviolet- curable polydimethylsiloxane microfluidic chips, Biomicrofluidics 11, 024120 (2017)
  • Roh YH, Sim SJ, Cho I-J, Choi N*, Bong KW*, Vertically encoded tetragonal hydrogel microparticles for multiplexed detection of miRNAs associated with Alzheimer’s disease, Analyst 141, 4578-4586 (2016); selected as the journal cover
  • Yeom SY, Son CH, Kim BS, Tag SH, Nam E, Shin H, Kim SH, Gang HM, Lee HJ, Choi J*, Im H- I*, Cho I-J*, Choi N*, Multiplexed Detection of Epigenetic Markers Using Quantum Dot (QD)-Encoded Hydrogel Microparticles, Analytical Chemistry 88, 4259-4268 (2016)
  • Kim JA, Kim HN, Im S-K, Chung S, Kang JY*, Choi N*, Collagen-based brain microvasculature model in vitro using three-dimensional printed template, Biomicrofluidics 9, 024115 (2015)
  • Morgan JP, Delnero PF, Zheng Y, Verbridge SS, Chen J, Craven M, Choi NW, Diaz-Santana A, Kermani P, Hempstead B, Lopez JA, Corso TN, Fischbach-Teschl C, Stroock AD, Formation of microvascular networks in vitro, Nature Protocols 8 (9), 1820-1836 (2013)
  • Choi NW, Kim J, Chapin SC, Duong T, Donohue E, Pandey P, Broom W, Hill WA, Doyle PS, Multiplexed detection of mRNA using porosity-tuned hydrogel microparticles, Analytical Chemistry 84, 9370-9378 (2012)
  • Zheng Y, Chen J, Craven M, Choi NW, Totorica S, Diaz-Santana A, Kermani P, Hempstead B, Fischbach-Teschl C, López JA, Stroock AD, In vitro microvessels for the study of angiogenesis and thrombosis, Proceedings of the National Academy of Sciences of the United States of America 109 (24), 9342-9347 (2012)
  • Choi NW†*, Verbridge SS†, Williams RM, Chen J, Kim JY, Schmehl R, Farnum CE, Zipfel