홍규상, Gyu-Sang Hong

Senior Researcher (PI)

OFFICE

L7401a, +82-2-958-6986

LAB

L7401, 411, 412

Info.

https://bsi.kist.re.kr/dt_team/honglab/

EDUCATION

MS/Ph.D. Medicine and Biopharmaceutical Sciences, Seoul National University (2010-2016)

B.S.  Bio & Nano chemistry Kookmin University, Seoul, Korea (2001-2008)

RESEARCH CAREER
  • Assistant Professor, Neuroscience in Division of Biomedical Sci. & Tech. in University of Science and Technology (KIST-School) (2021-Present)
  • Senior Researcher, Brain Science Institute, Korea Institute of Science and Technology (KIST) (2018-Present)
  • Postdoctoral Researcher, Brain Science Institute, Korea Institute of Science and Technology (KIST) (2016-2018)
  • Postdoctoral Researcher, Seoul National University (2016)
RESEARCH INTERESTS
  • Molecular Mechanism and Biophysics of Ion Channels
  • Understanding of Memory and Neurogenesis (Brain Disorders)
  • Development of Novel Drugs

Bok Eum Kang

Post-Doc (2021-Present)

EDUCATION

Ph.D. Neuroscience in Division of Biomedical Sci. & Tech. in University of Science and Technology (KIST-School)

BS DePauw University

RESEARCH INTERESTS
  • Memory Genesis in Hippocampus
  • Molecular mechanism of ion channel in Neural Stem Cells and Neurodevelopmental Disorders (Autism)
  • Development of Mechanosensor

Kyungmin Kim

Post-Doc (2021-Present)

EDUCATION

Researcher (2020)

MS/PhD in Seoul National University (2021)

BS in Catholic University of Korea

RESEARCH INTERESTS
  • Molecular mechanism of ion channel in Neural Stem Cells and Neurodevelopmental Disorders (Autism)
  • Memory Genesis in Hippocampus

Mi-Sun Kim

MS Researcher

EDUCATION

Researcher (2020-Present)

MS in Jeonbuk National University

RESEARCH INTERESTS
  • Pharmacological effect on Nervous system
  • Molecular mechanism of ion channel in Neural Stem Cells and Neurodevelopmental Disorders (Autism)

Taewoong Ha

Ph.D. Candidate

EDUCATION

Ph.D. candidate in Life Science , Korea University (KIST Student Researcher) (2020-Present)

BS. MS. Department of Convergence Biotechnology in Konkuk University

RESEARCH INTERESTS
  • Mechanobiology in Sensory Transduction
  • Pharmacological effect on Nervous system

Jungwoong Chu

MS/Ph.D. Candidate

EDUCATION

MS/PhD Course, Neuroscience in Division of Biomedical Sci. & Tech. in University of Science and Technology (KIST-School) (2021-Present)

BS. Bioengineering in Cha University

RESEARCH INTERESTS
  • Molecular mechanism of ion channel in Brain Disorders
  • Pharmacological effect on Nervous system

Hyeyoon Kim

Intern Researcher

EDUCATION

MS/PhD Course Candidate, Neuroscience in Division of Biomedical Sci. & Tech. in University of Science and Technology (KIST-School) (2022-Present)

Intern Researcher in KIST (2021)

BS. Bio Convergence in Kookmin University

RESEARCH INTERESTS
  • Molecular mechanism of ion channel in Neural Stem Cells and Neurodevelopmental Disorders (Autism)
  • Alzheimer’s disease
Research Summary
Research Summary
Research Highlight
  • Tentonin 3/TMEM150C senses blood pressure changes in the aortic arch.   Huan-Jun Lu,1,2 Thien-Luan Nguyen,1,2 Gyu-Sang Hong,1 Sungmin Pak,1 Hyesu Kim,1 Hyungsup Kim,1 Dong-Yoon Kim,3 Sung-Yon Kim,3 Yiming Shen,4 Pan Dong Ryu,4 Mi-Ock Lee,2 and Uhtaek Oh1.  J Clin Invest. 2020;130(7):3671–3683.
  • Ano1/TMEM16A Regulates Process Maturation in Radial Glial Cells in the Developing Brain. Hong GS*, Lee SH*, Lee BJ, Jang Y, Jung J, Kim IB, Oh U. Proc Natl Acad Sci U S A. (2019)
  • Evidence for Mechanosensitive Channel Activity of Tentonin 3/TMEM150C. Hong GS, Lee B, Oh U. Neuron (2017)
  • Tentonin 3/TMEM150c confers distinct mechanosensitive currents in dorsal-root ganglion neurons with proprioceptive function. Hong GS, Lee B, Wee J, Chun H, Kim H, Jung J, Cha JY, Riew TR, Kim GH, Kim IB, Oh U. Neuron (2016)
  • Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia. Cha JY, Wee J, Jung J, Jang Y, Lee B, Hong GS, Chang BC, Choi YL, Shin YK, Min HY, Lee HY, Na TY, Lee MO, Oh U. Proc Natl Acad Sci U S A. Aug 4;112(31):9722-7. doi: 10.1073/pnas.1423827112. Epub 2015 Jul 7. (2015) 
  • A role for Piezo2 in EPAC1-dependent mechanical allodynia. Eijkelkamp N, Linley JE, Torres JM, Bee L, Dickenson AH, Gringhuis M, Minett MS, Hong GS, Lee E, Oh U, Ishikawa Y, Zwartkuis FJ, Cox JJ, Wood JN. Nat Commun. 2013;4:1682. doi: 10.1038/ncomms2673. (2013)
Mechano
Mechanobiology and Ion Channels

We are attempting to answering the question of

‘How physical forces affect neural cells and contribute to physiology and brain disorders?’

“What is the roles for ion channels in the nervous system?’

1. Neural Cell based Mechanobiology and underlying Brain Disorders

(Neural Stem Cells, Synaptic Transmission in the brain, Sensory Transduction)

2. Activation Mechanism and the physiological roles of Ion Channels in the Nervous System

Mechanobiology
Patch systems
Neuroscience_01_cover