권석규, Seok-Kyu Kwon

Senior Researcher

OFFICE

L7205, +82-2-958-7217

LAB

L7205, +82-2-958-

EDUCATION

Ph.D. Department of Biological Sciences, KAIST (2010)

B.S. Department of Biological Sciences, KAIST (2005)

RESEARCH CAREER & ACTIVITIES
  • 2018.03~current: Senior researcher, KIST, Seoul, Republic of Korea
  • 2013.11~2017.12: Postdoctoral Fellow, Columbia University, New York, NY, USA
  • 2011.05~2013.10: Postdoctoral Fellow, The Scripps Research Institute, La Jolla, CA, USA
  • 2010.09~2011.04: Postdoctoral Fellow, KAIST, Daejeon, Republic of Korea
RESEARCH INTERESTS
  • ER & mitochondrial function for synaptic transmission
  • Developing new imaging techniques for monitoring ER, mitochondria, and synaptic function
  • Exploring mitochondrial distribution and function in various circuits
HIGHLIGHT
  • ER-mitochondria tethering by PDZD8 regulates Ca2+ dynamics in mammalian neurons Hirabayashi Y*, Kwon SK*, Paek H, Pernice W, Paul MA, Lee J, Erfani P, Raczkowski A, Petrey DS, Liza A. Pon LA and Polleux F. (2017) (* co-first author) Science 358, 623–630 (2017)
  • LKB1 regulates mitochondria-dependent presynaptic calcium clearance and neurotransmitter release properties at excitatory synapses along cortical axons Kwon SK, Sando R, Lewis TL, Hirabayashi Y, Maximov A and Polleux F. (2016)
    PLoS Biology. 14(7):e1002516 (2016)
  • IgSF9b is coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development. Woo J*, Kwon SK*, Nam JY*, Choi SW*, Takahashi H*, Krueger D, Park JH, Bae JY, Ko JW, Lee DM, Kim H, Kim MH, Bae YC, Chang SH, Craig AM and Kim E. (2013)(* co-first author)Journal of Cell Biology, 201:929-944
  • Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, PTPδ, and PTPσ via specific domains regulate excitatory synapse formation. Kwon SK*, Woo J*, Kim SY, Kim H and Kim E. (2010). (* co-first author) J. Biol. Chem. 285:13966-13978
  • Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses. Woo J*, Kwon SK*, Choi S, Kim S, Lee JR, Dunah AW, Sheng M and Kim E. (2009). (*co-first author) Nature Neuroscience 12:428-437.