임상민, Lim, Sang Min

Senior Researcher

OFFICE

L2103, +82-2-958-5134

LAB

L2137, +82-2-958-5175

HOMEPAGE

https://sites.google.com/site/smlimlab/

EDUCATION

Ph.D. Department of Chemistry and Chemical Biology, Harvard University (2013)
M.S. Department of Chemistry, Seoul National University (2004)
B.S. Department of Chemistry, Seoul National University (2002)

RESEARCH CAREER & ACTIVITIES
  • Senior Research Scientist, Brain Science Institute, Korea Institute of Science and Technology (2016-present)
  • Principal Research Fellow, Center for Catalytic Hydrocarbon Functionalizations, Institute of Basic Science (2015-2016)
  • Postdoctoral Fellow, California Institute for Biomedical Research (2013-2015)
RESEARCH INTERESTS
  • Drug Development for Brain Diseases including Neurodegenerative Diseases
  • Synthesis of Chemical Probes for Novel Targets in Brain Diseases
HIGHLIGHT
  • Small Molecule Selectively Suppresses MYC Transcription in Cancer Cells. Bouvard, C.; Lim, S. M.; Ludka, J.; Yazdani, N.; Woods, A. K.; Chatterjee, A. K.; Schultz, P. G.*; Zhu, S.*  Proc. Natl. Acad. Sci. USA 2017, 114, 3497-3502
  • Identification of β-Lapachone Analogs as Novel MALT1 Inhibitors to Treat an Aggressive Subtype of Diffuse Large B-cell Lymphoma. Lim, S. M.; Jeong, Y.; Lee, S.; Im, H.; Tae, H. S.; Kim, B. G.; Park, H. D.; Park, J.*; Hong, S.* J. Med. Chem. 2015, 58, 8491-8502.
  • Pharmacological Targeting of the Pseudokinase Her3. Xie, T.; Lim, S. M.; Westover, K. D.; Dodge, M. E.; Ercan, D.; Ficarro, S. B.; Udayakumar, D.; Tae, H. S.; Riddle, S. M.; Sim, T.; Marto, J. A.; Jänne, P. A.*; Crews, C. M.*; Gray, N. S.*  Nat. Chem. Biol. 2014, 10, 1006-1012.
  • Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor. Lim, S. M.; Westover, K. D.; Ficarro, S. B.; Harrison, R. A.; Choi, H. G.; Pacold, M. E.; Carrasco, M.; Hunter, J.; Kim, N. D.; Xie, T.; Sim, T.; Jänne, P. A.; Meyerson, M.; Marto, J. A.; Engen, J.; Gray, N. S.* Angew. Chem., Int. Ed. 2014, 53, 199-204