임상민, Lim, Sang Min

Senior Researcher

OFFICE

L2103, +82-2-958-5134

LAB

L2137, +82-2-958-5175

HOMEPAGE

EDUCATION

Ph.D. Department of Chemistry and Chemical Biology, Harvard University (2013)
M.S. Department of Chemistry, Seoul National University (2004)
B.S. Department of Chemistry, Seoul National University (2002)

RESEARCH CAREER & ACTIVITIES
  • Senior Research Scientist, Brain Science Institute, Korea Institute of Science and Technology (2016-present)
  • Principal Research Fellow, Center for Catalytic Hydrocarbon Functionalizations, Institute of Basic Science (2015-2016)
  • Postdoctoral Fellow, California Institute for Biomedical Research (2013-2015)
RESEARCH INTERESTS
  • Drug Development for Brain Diseases including Neurodegenerative Diseases
  • Synthesis of Chemical Probes for Novel Targets in Brain Diseases
HIGHLIGHT
  • Small Molecule Selectively Suppresses MYC Transcription in Cancer Cells. Bouvard, C.; Lim, S. M.; Ludka, J.; Yazdani, N.; Woods, A. K.; Chatterjee, A. K.; Schultz, P. G.*; Zhu, S.*  Proc. Natl. Acad. Sci. USA 2017, 114, 3497-3502
  • Identification of β-Lapachone Analogs as Novel MALT1 Inhibitors to Treat an Aggressive Subtype of Diffuse Large B-cell Lymphoma. Lim, S. M.; Jeong, Y.; Lee, S.; Im, H.; Tae, H. S.; Kim, B. G.; Park, H. D.; Park, J.*; Hong, S.* J. Med. Chem. 2015, 58, 8491-8502.
  • Pharmacological Targeting of the Pseudokinase Her3. Xie, T.; Lim, S. M.; Westover, K. D.; Dodge, M. E.; Ercan, D.; Ficarro, S. B.; Udayakumar, D.; Tae, H. S.; Riddle, S. M.; Sim, T.; Marto, J. A.; Jänne, P. A.*; Crews, C. M.*; Gray, N. S.*  Nat. Chem. Biol. 2014, 10, 1006-1012.
  • Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor. Lim, S. M.; Westover, K. D.; Ficarro, S. B.; Harrison, R. A.; Choi, H. G.; Pacold, M. E.; Carrasco, M.; Hunter, J.; Kim, N. D.; Xie, T.; Sim, T.; Jänne, P. A.; Meyerson, M.; Marto, J. A.; Engen, J.; Gray, N. S.* Angew. Chem., Int. Ed. 2014, 53, 199-204