류훈, Ryu, Hoon

Principal Researcher

OFFICE

L7413, +82-958-6855

LAB

L7413, +82-958-6848

EDUCATION

Ph.D. Neuroendocrinology, Graduate School, Chonbuk National University (1992)
M.S. Neuroendocrinology, Graduate School, Chonbuk National University (1989)
B.S. Biology, College of Natural Sciences, Chonbuk National University (1983)

RESEARCH CAREER & ACTIVITIES
  • Head, Center for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology (2019-present)
  • Adjunct Associate Professor, Department of Neurology, Boston University School of Medicine, MA, USA (2020-Present)
  • Associate Professor, Department of Neurology, Boston University School of Medicine, MA, USA (2007-2019)
  • WCU Professor, Department of Biomedical Sciences, Seoul National University School of Medicine (2009-2013)
  • Principal Investigator, Boston University Alzheimer’s Disease Center (BU ADC), Boston University School of Medicine, MA, USA (2009-Present)
  • Director, Laboratory for Neuronal Gene Regulation & Epigenetics, VA Boston Healthcare System, MA, USA (2009-2019)
  • Assistant Professor, Department of Neurology, Boston University School of Medicine, MA, USA (2004-2005)
  • Instructor, Harvard Medical School and Department of Neurology, Beth Israel Deaconess Medical Center, MA, USA (1999-2003)
  • Research Associate, Harvard Medical School and Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, MA, USA (1997-1999)
RESEARCH INTERESTS
  • Mechanisms of gene regulation and epigenetic modification in the pathogenesis of brain disorders including Alzheimer’s disease (AD), Huntington’s disease (HD), and traumatic brain injury (TBI).
  • Cell and non-cell autonomous mechanisms of neurodegeneration.
  • Development of new neurotherapeutic strategies combined with translational (preclinical) study in animal models of brain disorders.
HIGHLIGHT
  • Lee JY, Se Han SH, Park MH, Baek B, Song I-S, Choi M-K, Takuwa Y, Ryu H, Kim SH, He X, Schuchman EH, Bae J-S, Jin HK. (2018) Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s disease. Nat. Commun. 9:1479.
  • Lee J, Hwang YJ, Kim Y, Lee MY, Hyeon SJ, Lee S, Kim DH, Jang SJ, Im H, Min SJ, Choo H, Pae AN, Kim DJ, Cho KS, Kowall NW, Ryu H.* (2017) Remodeling of heterochromatin structure slows neuropathological progression and prolongs survival in an animal model of Huntington’s disease. Acta Neuropathol. 134(5):729-748.
  • Hong C, Kwak M, Myeong J, Hwang YJ, Ha K, Kim I-G, Jeon J-H, Ryu H*, So I*. (2015) Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington’s disease. Brain. 138:3030-3047. *Co-Corresponding authors.
  • Kim YH, Kim KY, Hwang YJ, Kowall NW, Lee SB, Lee J and Ryu H. (2015) Uvrag targeting by MiR-125a and MiR-351 modulates autophagy associated with EWS deficiency. Autophagy. 11(5):796-811.
  • Jo S, Yarishkin O, Hwang YJ, Woo DH, Park M, Kim T, Lee J, Chun H, Park HJ, Bae JY, Park SJ, Lee H, Yoon B-E, Shim IS, Bae YC, Cho J, Kowall NW, Ryu H, Hwang E, Kim D and Lee CJ. (2014) Glial GABA masks memory in mouse models of Alzheimer’s disease. Nat. Med. 20:886-896.
  • Koh D-I, Han D, Ryu H, Choi W-I, Kim M-K, Jeon B-N, Kim Y, Kim JY, Parry L, Clarke AR, Reynolds AB, Hur M-W. (2014) KAISO, a critical regulator of p53 mediated transcription of CDKN1A and apoptotic genes. Proc. Natl. Acad. Sci. USA. 111:15078-15083.
  • Lee J, Hwang YJ, Shin J-Y, Lee W-C, Wie J, Kim KY, Lee MY, Hwang D, Ratan RR, Kowall NW, So I, Kim J-I and Ryu H. (2013) Epigenetic regulation of cholinergic receptor M1 (CHRM1) by histone H3K9me3 impairs Ca2+ signaling in Huntington’s disease. Acta Neuropathol. 125:727-739.
  • Lee JK, Shin JH, Hwang SG, Gwag BJ, McKee A, Kowall NW, Ryu H, Lim D-S, and Choi E-J. (2013) MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS. Proc. Natl. Acad. Sci. USA. 110:12066-12071.