최낙원, Nakwon Choi

Principal Researcher

OFFICE

L7332, +82-958-6742

LAB

L7336, L7226, L7327

EDUCATION
Ph.D. Chemical Engineering, Cornell University (2010)
M.S. Chemical Engineering, Cornell University (2008)
B.S. Chemical Engineering, Seoul National University (2004)

RESEARCH CAREER & ACTIVITIES

Mar. 2017 – Present

  • Principal Researcher, Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST)

Jan. 2012 – Feb. 2017

  • Senior Researcher, Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST)

Jun. 2010 – Dec. 2011

  • Presidential Postdoctoral Fellow, Hit Discovery Group, Center for Proteomic Chemistry, Lead Finding Platform, Novartis Institutes for Biomedical Research (NIBR), Cambridge, MA, USA
  • Research Affiliate (Postdoctoral Fellow), Department of Chemical Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA

Jan. 2010 – May 2010

  • Postdoctoral Associate, School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA

Aug. 2004 – Dec. 2009

  • Research Assistant/Teaching Assistant, School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA
RESEARCH INTERESTS
  • Brain/neural tissue engineering: development of brain-on-chips (physiologically relevant 3D culture platforms) such as neural circuit-on-a chip, neurovascular unit (NVU)-on-a chip, and blood-brain barrier (BBB)-on-a chip
  • Brain neural tissue engineering: development of disease models in vitro based on brain-on- chips such as brain tumor and Alzheimer’s disease
  • Hydrogel-based in vitro diagnostics and prognosis: development of hydrogel-based bioassays for multiplex detection of DNAs (qPCR), miRNAs, and proteins associated with various diseases including neurodegenerative diseases
HIGHLIGHT
  • Choi W†, Yeom SY†, Kim J, Jung S, Jung S, Shim TS, Kim SK, Kang JY, Lee SH, Cho I-J, Choi J*, Choi N*, Hydrogel micropost-based qPCR for multiplex detection of miRNAs associated with Alzheimer’s disease, Biosensors and Bioelectronics 101, 235-244 (2018)
  • Kim SH†, Im S-K†, Oh S-J†, Jeong S, Yoon E-S, Lee CJ, Choi N*, Hur E-M*, Anisotropically organized three- dimensional culture platform for reconstruction of a hippocampal neural network, Nature Communications 14346 (2017); highlighted in Nature Reviews Materials
  • Kim J, An H, Seo Y, Jung Y, Lee JS, Choi N*, Bong KW*, Flow lithography in ultraviolet- curable polydimethylsiloxane microfluidic chips, Biomicrofluidics 11, 024120 (2017)
  • Roh YH, Sim SJ, Cho I-J, Choi N*, Bong KW*, Vertically encoded tetragonal hydrogel microparticles for multiplexed detection of miRNAs associated with Alzheimer’s disease, Analyst 141, 4578-4586 (2016); selected as the journal cover
  • Yeom SY, Son CH, Kim BS, Tag SH, Nam E, Shin H, Kim SH, Gang HM, Lee HJ, Choi J*, Im H- I*, Cho I-J*, Choi N*, Multiplexed Detection of Epigenetic Markers Using Quantum Dot (QD)-Encoded Hydrogel Microparticles, Analytical Chemistry 88, 4259-4268 (2016)
  • Kim JA, Kim HN, Im S-K, Chung S, Kang JY*, Choi N*, Collagen-based brain microvasculature model in vitro using three-dimensional printed template, Biomicrofluidics 9, 024115 (2015)
  • Morgan JP, Delnero PF, Zheng Y, Verbridge SS, Chen J, Craven M, Choi NW, Diaz-Santana A, Kermani P, Hempstead B, Lopez JA, Corso TN, Fischbach-Teschl C, Stroock AD, Formation of microvascular networks in vitro, Nature Protocols 8 (9), 1820-1836 (2013)
  • Choi NW, Kim J, Chapin SC, Duong T, Donohue E, Pandey P, Broom W, Hill WA, Doyle PS, Multiplexed detection of mRNA using porosity-tuned hydrogel microparticles, Analytical Chemistry 84, 9370-9378 (2012)
  • Zheng Y, Chen J, Craven M, Choi NW, Totorica S, Diaz-Santana A, Kermani P, Hempstead B, Fischbach-Teschl C, López JA, Stroock AD, In vitro microvessels for the study of angiogenesis and thrombosis, Proceedings of the National Academy of Sciences of the United States of America 109 (24), 9342-9347 (2012)
  • Choi NW†*, Verbridge SS†, Williams RM, Chen J, Kim JY, Schmehl R, Farnum CE, Zipfel
Lab Members

Songhyun Lee

Postdoctoral Fellow

Education

B.S. Electronics, Radio and Information Communications Engineering, Chungnam National University (2007)

M.S. Information & Communications Engineering, Gwangju Institute of Science and Technology (2011)

Ph.D. Biomedical Engineering, Gwangju Institute of Science and Technology (2018)

Post-Doc. Gwangju Institute of Science and Technology (2018.03~2018.05)

Research Interests
  • Organ-on-a-chip, vascularized organoids and neural/muscle circuit

Yousang Yoon

Postdoctoral Fellow

Education

B.S. Electronic Engineering, Hanyang University (2012)

Ph.D. Electronics and Computer Engineering, Hanyang University (2019)

Research Interests
  • Hydrogel-based bioassay

Woongsun Choi

M.S./Ph.D. Student (Ph.D. candidate)

Education

B.S. Chemical & Biological Engineering, Korea University (2015)

Research Interests
  • Hydrogel-based bioassay

Sohyeon Jeong

M.S./Ph.D. Student (Ph.D. candidate)

Education

B.S. Food Science and Technology, Seoul National University of Science and Technology (2015)

Research Interests
  • 3D in vitro culture platform for reconstruction of neural circuit

Junbeom Kim

M.S./Ph.D. Student (Ph.D. candidate)

Education

B.S. Chemical & Biological Engineering, Korea University (2016)

Research Interests
  • Hydrogel-based bioassay

Hyunwook Kang

M.S./Ph.D. Student 

Education

B.S. Mechanical Engineering, Korea University (2018)

Research Interests
  • 3D in vitro culture platforms

Sviatlana Belaya

M.S./Ph.D. Student 

Education

B.S. Biological Faculty, Belarusian State University (2017)

Research Interests
  • Hydrogel-based bioassay

So Hyun Kim

Alumni (KIST Star Postdoctoral Fellow)

Education

B.S. Nano Biotechnology, Ewha Womans University (2004)

M.S. Nano Biotechnology, Ewha Womans University (2008)

Ph.D. Nano Biotechnology, Ewha Womans University (2011)

Neurosurgery researcher, Ilsan Paik Hospital (2004 ~ 2006)

Researcher, Center for Intelligent Nano-Bio Materials (2011 ~ 2013)

KIST Star Postdoctoral Fellow (2013 ~ 2016)

Currently @ Research center for Anti-cancer Treatment, SK biopharmaceuticals

Research Interests
  • 3D in vitro culture platform for reconstruction of neural circuit

Sangyun Yeom

Alumni (M.S.)

Education

M.S. Chemical & Biological Engineering, Korea University (2016)

B.S. Chemical & Biological Engineering, Korea University (2014)

Currently @ LG Chem Ltd.

Research Interests
  • Hydrogel-based bioassay

Brittany Sincox

Alumni (Intern)

Education

Currently @ M.Res./Ph.D., Neuroscience, University College London and National Institutes of Health

B.S. Biochemistry, Grand Valley State University (2019)

Research Interests
  • Hydrogel-based bioassay
Research Keywords