Senior Researcher
OFFICE L7133, +82-2-958-6940
LAB L7133, +82-2-958-6957, 6981
E-mail khan@kist.re.kr
ABOUT LAB The Laboratory of Computational Neurophysics (LCNP) at Korea Institute of Science and Technology (KIST) is a group of researchers who use theoretical methods combined with high-performance computing to investigate the diverse biophysical phenomena, with an emphasis on the information processing mechanism of the brain. The Lab operates under the direction of Dr. Kyungreem Han.
EDUCATION
Ph.D. Pharmacy, Seoul National University (2013)
Thesis title: Development of mathematical models for the assessment and prediction of β-cell functions
B.S. Pharmacy, Seoul National University (2006)
RESEARCH CAREER & ACTIVITIES
- Postdoctoral Fellow, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA (2017-2020)
- Visiting Fellow (supported by Korean Government), NHLBI, National Institutes of Health, Bethesda, MD 20892, USA (2015-2017)
- Postdoctoral Fellow, Center for Theoretical Physics, Seoul National University, Seoul 08826, South Korea (2013-2015)
- Visiting Scientist, Department of Physiology and Biophysics, University of Washington, WA 98195, USA (2012.12)
RESEARCH INTERESTS
- Development of multiscale modeling/simulation methods for biophysical systems
- Neural Information Theory
- The natural intelligence-based deep learning algorithm
- Graph theory & Network analysis
- Molecular dynamics simulations:
Lipid-protein interaction, Ion channel, and Free energy calculation - Complex systems modeling:
Excitable cells (neuron and β-cell), Autophagy, Amyloid-β, and Glucose regulation
HIGHLIGHT
- Soon Ho Kim, JunHyuk Woo, Kiri Choi, MooYoung Choi, Kyungreem Han*. Neural information processing and computations of two-input synapses. Neural Computation (2022) in press *corresponding author
- Kyungreem Han, Soon Ho Kim, Richard M. Venable, Richard W. Pastor. Design Principles of PI(4,5)P2 Clustering Under Protein-Free Conditions: Specific Cation Effects and Calcium-Potassium Synergy. Proceedings of the National Academy of Sciences 119 (22): e2202647119. (2022)
- In-Ryeong Choi, Kyungreem Han, MooYoung Choi. Complex-systemic evolution of language through an integrated study of humanities and neuroscience. Language and Linguistics 96: 113-146. (2022)
- Jae-Gyum Kim, Hayom Kim, Jihyeon Hwang, Sung Hoon Kang, Chan-Nyoung Lee, JunHyuk Woo, Chanjin Kim, Kyungreem Han, Jung Bin Kim, Kun-Woo Park. Differentiating amnestic from non-amnestic mild cognitive impairment subtypes using graph theoretical measures of electroencephalography. Scientific Reports 12: 6219. (2022)
- JunHyuk Woo, KiriChoi, Soon Ho Kim, MooYoung Choi*, Kyungreem Han*. The structural aspects of neural dynamics and information flow. Frontiers in Bioscience (Landmark edition) 27(1): 015 (2022) *corresponding author
- JunHyuk Woo, Soon Ho Kim, Kyungreem Han*, MooYoung Choi*. Characterization of dynamics and information processing ofintegrate-and-fire neuron models. Journal of Physics A: Mathematical and Theoretical 54: 445601. (2021) *corresponding author
- JunHyukWoo†,Kiri Choi†, Soon Ho Kim†, Kyungreem Han*, MooYoung Choi*. Characterization of information processing in the neural-logiccircuits. Frontiers in Bioscience (Landmark edition) 26(10): 723-739. (2021) †These authors contributedequally to this work. *corresponding author
- HayomKim, Sung Hoon Kang, Soon Ho Kim, Seong Hwan Kim, Jihyeon Hwang, Jae-GyumKim, Kyungreem Han*, Jung Bin Kim*. Drinking coffee enhances neurocognitive function by reorganizing brain functional connectivity. Scientific Report 11: 14381.(2021) *corresponding author
- Jung-Hwan Kim, Tsutomu Matsubara, Jaekwon Lee, Cristina Fenollar-Ferrer, Kyungreem Han, Donghwan Kim, Shang Jia,Christopher J Chang, Heejung Yang, Tomokazu Nagano, Kristopher W Krausz, Sun-HeeYim, Frank J Gonzalez. Lysosomal SLC46A3 modulates hepatic cytosolic copperhomeostasis. Nature Communications 12(1): 290. (2021)
- Kyungreem Han, Richard W. Pastor, Cristina Fenollar-Ferrer. PLD2–PI(4,5)P2 Interactions in Fluid Phase Membranes: StructuralModeling and Molecular Dynamics Simulations. PLoS ONE 15(7): e0236201. (2020)
- Kyungreem Han, Arne Gericke, Richard W. Pastor. Characterization of specific ion effects on PI(4,5)P2 clustering: molecular dynamics simulations and graph-theoretic analysis. The Journal of Physical Chemistry B 124 (7): 1183-1196. (2020)
- Kyungreem Han*, Soon Ho Kim, MooYoung Choi*. Computational modeling of the effects of autophagy on amyloid-β peptide levels. Theoretical Biology and Medical Modelling 17 (2): 1-16. (2020) *corresponding author
- Kyungreem Han*, Phillip S. Hudson, Michael R. Jones, Naohiro Nishikawa, Florentina Tofoleanu, Bernard R. Brooks. Prediction of CB[8] host-guest binding free energies in SAMPL6 using the double-decoupling method. Journal of Computer-Aided Molecular Design 32 (10):1059–1073. (2018) *corresponding author
- Kyungreem Han, Richard M. Venable, Anne-Marie Bryant, Christopher J. Legacy, Rong Shen, Hui Li, Benoît Roux, Arne Gericke, and Richard Walter Pastor. Graph-Theoretic Analysis of Monomethyl Phosphate Clustering in Ionic Solutions. The Journal of Physical Chemistry B 122: 1484-1494. (2018)
- Yongsoo Park, Jong Bae Seo, Alicia Fraind, Angel Pérez-Lara, Kyungreem Han, Seung-Ryoung Jung, MooYoung Choi, David S. Cafiso, Duk-Su Koh, Reinhard Jahn. Synaptotagmin-1 binds to PIP2-containing membrane but not to SNAREs at physiological ionic strength. Nature Structural & Molecular Biology 22(10):815-823. (2015)
- Kyungreem Han, Hyun Woong Kwon, Hyuk Kang, Jinwoong Kim, Myung-Shik Lee, M.Y. Choi. Dynamics of macroautophagy: Modeling and oscillatory behavior. Physica A 391(3): 686-692. (2012)