성지혜, Seong, Jihye

Senior Researcher

OFFICE

L2215, +82-958-5904

LAB

L2124, +82-958-5908

EDUCATION

Ph.D. Neuroscience, University of Illinois at Urbana-Champaign (2012)

M.S. Pharmacy, Seoul National University (2005)

B.S. Pharmacy, Seoul National University (2003)

RESEARCH CAREER & ACTIVITIES
  • Senior Researcher, Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Center for Neuromedicine, Korea Institute of Science and Technology (KIST) (2015-Present)
  • Associate Professor, Bio-Medical Science & Technology, KIST School, UST (2016-Present)
  • Adjunct Professor, Converging Science and Technology, Kyung Hee University (2015-Present)
  • Researcher, Center for Neuromedicine, KIST (2014-2015)
  • Postdoctoral Researcher, Stanford University (2013)
RESEARCH INTERESTS
  • Development of molecular fluorescent biosensors to detect neurotransmission & Live-cell imaging of dynamic signaling events
  • Development of new optogenetic strategy to control neurotransmission to study how it regulates neuronal functions
  • Investigation of molecular mechanisms of Neurodegenerative diseases (Alzheimer’s disease, Huntington’s disease) utilizing cutting-edge fluorescent imaging techniques in live cells
HIGHLIGHT
  • Engineered Proteins with Sensing and Activating Modules for Automated Reprogramming of Cellular Functions. Sun J; Lei L; Tsai C-M; Wang Y; Shi Y; Ouyang M; Lu S; Seong J; Kim T-J; Wang P; Huang M; Xu X; Nizet V; Chien S; Wang Y.  Nature Communications 2017, Sep 7;8(1):477
  • FRET-based Visualization of PDGF Receptor activation at membrane microdomains. Seong J*; Huang M; Sim KM; Kim H; Wang Y. Scientific Reports 2017, May 9;7(1):1593
  • Identification of actin as a direct proteomic target of berberine using an affinity-based chemical probe and elucidation of its modulatory role in actin assembly. Yi CM; Yu J; Kim H; Lee NR; Kim SW; Lee NJ; Lee J; Seong J*; Kim NJ*; Inn KS*. Chemical Communications 2017, Jun 27;53(52):7045-7047
  • Distinct Mechanism of FAK Mechanoactivation by Different Extracellular Matrix Proteins. Seong J; Tajik A; Sun J; Guan J-L; Humphries MJ; Craig SE; Shekaran A; Garcia AJ; Wang N, Wang Y.  Proc. Natl. Acad. Sci. USA. 2013, Nov 26;110(48):19372-7 (Selected by F1000Prime Biology) 
  • Detect FAK Activations at Membrane Microdomains by FRET. Seong J; Ouyang M; Kim T; Sun J; Wen P-C; Lu S; Llewellyn NM; Schlaepfer DD; Guan J-L; Chien S; Wang Y. Nature Communications 2011, Jul 26;2:406.