성지혜, Seong, Jihye
Principal Researcher
EDUCATION
Ph.D. Neuroscience, University of Illinois at Urbana-Champaign (2012)
M.S. Pharmacy, Seoul National University (2005)
B.S. Pharmacy, Seoul National University (2003)
RESEARCH CAREER & ACTIVITIES
- Principal Researcher, Brain Science Institute, KIST (2020-Present)
- Senior Researcher, Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, KIST (2015-2019)
- Associate Professor, Bio-Medical Science & Technology, KIST School, UST (2016-Present)
- Adjunct Professor, Converging Science and Technology, Kyung Hee University (2015-Present)
- Researcher, Center for Neuromedicine, KIST (2014-2015)
- Postdoctoral Researcher, Stanford University (2013)
RESEARCH INTERESTS
- Development of fluorescent protein (FP)-based biosensors to detect cellular and molecular events, such as neurotransmission, autophagy, immune response, cell motility etc.
- Development of new optobiochemical strategy to control protein activity and function, e.g. neurotransmission and cell motility
- Investigation of dynamic cellular mechanisms and pathology of neurodegenerative diseases utilizing cutting-edge fluorescent sensing and optobiochemical techniques in live cells
HIGHLIGHT
- Optobiochemistry: Genetically encoded control of protein activity by light. Seong J*; Lin MZ*. Annual Review of Biochemistry, 2021, Vol. 90
- Spatiotemporal kinetics of GPCR activity and function during endosomal trafficking pathway, Kim H; Lee HN; Choi J*;Seong J*. Analytical Chemistry 2021, Feb 2;93(4):2010-2017
- Visualization of autophagy progression by Red-Green-Blue autophagy sensor, Kim HJ; Kim H; Choi J; Inn K-S*;Seong J*, ACS Sensors, 2020, Dec 24;5(12):3850-3861
- Aβ modulates actin cytoskeleton via SHIP2-mediated phosphoinositide metabolism. Lee HN; Sim KM; Kim H; Ju J; Pae AN; Park JB; Ryu H, Seong J*. Scientific Reports, 2019, Oct 29;9(1):15557.
- Identification of actin as a direct proteomic target of berberine using an affinity-based chemical probe and elucidation of its modulatory role in actin assembly, Yi CM, Yu J, Kim H, Lee NR, Kim SW, Lee NJ, Lee J, Seong J*, Kim NJ*, Inn KS*, Chemical Communications. 2017, Jun 27;53(52):7045-7047