조일주, Il-Joo Cho

Principal Investigator

OFFICE

L7332B, +82-958-6754

HOMEPAGE

EDUCATION
Ph.D. Electrical Engineering, Department of EECS, KAIST (2004)
M.S. Electrical Engineering, Department of EECS, KAIST (2000)
B.S. Electrical Engineering, Department of EECS, KAIST (1998)

RESEARCH CAREER & ACTIVITIES
  • Principal Research Scientist, Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST) (2016-Present)
  • Senior Research Scientist, Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST) (2010-2016)
  • Visiting Research Scientist, EECS, University of Michigan, Ann Arbor (2008-2010)
  • Research Fellow, EECS, University of Minnesota, Minneapolis (2007-2008)
  • Senior Research Scientist, LG Electronics Institute of Technology, Seoul (2004-2007)
RESEARCH INTERESTS
  • MEMS Neural Probe System for recording neural activity with various stimulation (optogenetics, chemical delivery)
  • Miniaturized fluorescence detection system in-vivo
  • Miniaturized platforms with electrophysiology for artificial neural circuit with spheroid, organoid

Namsun Choo

Post-docs

EDUCATION
Ph.D. Mechatronics, School of Mechanical Engineering, GIST (2016)
M.S. Mechatronics, School of Mechanical Engineering, GIST (2011)
B.S. Mechanical Engineering, Konkuk University (2009)

RESEARCH INTERESTS
  • MEMS Neural Probe System for recording neural activity with various stimulation (optogenetics, chemical delivery)
  • Miniaturized fluorescence detection system in-vivo

Donghak Byun

Post-docs

EDUCATION
Ph.D. Mechatronics, School of Mechanical Engineering, GIST (2017)
B.S. Mechanical Engineering, Department of Mechanical System Engineering, Chonnam National University (2010)

RESEARCH INTERESTS
  • Micro fluidic systems for differentiation and culture of organoids
  • Study on the effect of CNTs incorporated in intermediate collagen block between blocks embedding neurons

Yousang Yoon

Post-docs

EDUCATION
Ph.D. Electronics and Computer Engineering, Department of ECE, Hanyang University (2019)
B.S. Electronic Engineering, Department of EE, Hanyang University (2012)

RESEARCH INTERESTS
  • Multifunctional neural probe
  • Microfluidic cell manipulation
  • Label-free bioassay

Jyungpyo Lee

Researcher

EDUCATION
M.S. Mechanical Engineering, Department of ME, Yonsei University (2017)
B.S. Mechanical Engineering, Department of ME, Yonsei University (2015)

RESEARCH INTERESTS
  • 3D neural cell culture system with nanomaterials
  • Non-invasive neuromodulation System by ultrasound

Hyogeun Shin

Graduate Students

EDUCATION
Ph.D. candidate Biomedical Engineering, KIST School, UST (2014~)
B.S. Electrical Engineering, Myongji university (2014)  

RESEARCH INTERESTS
  • MEMS Neural Probe System for recording neural activity with various stimulation (optogenetics, chemical delivery)
  • Miniaturized lensless fluorescent imaging system

Uikyu Chae

Graduate Students

EDUCATION
Ph.D. candidiate School of Electrical Engineering, Korea University (2015 ~ )
B.S. Department of Electronics and Communications Engineering, Kwangwoon University (2015)

RESEARCH INTERESTS
  • MEMS neural probe system for recording electrical and chemical neural activity (push-pull sampling probe(microdialysis), chemical delivery)
  • MEMS actuator with electrostatic force and thermal actuation (RF MEMS switch)

Donghyun Roh

Graduate Students

EDUCATION
M.S. School of Electrical Engineering, Department of ECE, Korea Univ. (2018)
B.S. Intensive for Electronic Engineering, Department of EIE, Sejong Univ. (2015)

RESEARCH INTERESTS
  • Photopolymerization system for fabrication of 3D hydrogel scaffold with multiple components
  • Miniaturized wireless multi-channel neural signal recording system for freely moving small animals (mice)

Kyeongseob Hwang

Graduate Students

EDUCATION
Ph.D. candidate Mechanical Engineering, Yonsei University (2017 ~ )
B.S. Department of Nano Optical Engineering, Korea Polytechnic University (2017)

RESEARCH INTERESTS
  • Miniaturized platforms for artificial neural circuit with spheroids and organoids

Uijin Jeong

Graduate Students

EDUCATION
M.S. candidate School of Electrical Engineering, Korea University (2019 ~ )
B.S. Biomedical Engineering, Korea University (2018)

RESEARCH INTERESTS
  • Animal behavioral experiments with multifunctional neural probe
  • Development miniaturized multifunctional neural probe
Neural probe for optogenetics

Integration of optical stimulation modalities on a large array of neural probes can enable an investigation of important underlying mechanisms of brain disorders that is not possible through neural recordings alone.

Optogenetics promises exciting neuroscience research by offering optical stimulation of neurons with unprecedented temporal resolution, cell-type specificity and the ability to excite as well as to silence neurons. This work provides the technical solution to deliver light to local neurons and record neural potentials, facilitating local circuit analysis and bridging the gap between optogenetics and neurophysiology research.

Neural probe for drug delivery

Neural probes integrated with microfluidic channels for direct brain infusion are of great interest because of the continuously increasing need to assess the efficacy of new pharmaceutical drugs and to investigate the roles of various neurotransmitters.

We present a neural probe with an embedded microfluidic channel (chemtrode) with multi-drug delivery capability suitable for small animal experiments. Chemtrodes enable not only targeted drug delivery with an accurate estimation of concentration and quantity of drugs applied on targeted neurons, but also allows near real-time monitoring of changes in neural signals during drug delivery.

Study of neural circuit with multifunctional Neural Probe

Mapping the brain and peripheral circuits may be the grandest challenge in all of science today. Our mission is to help neuroscientists, neurologists, and other clinicians understand these amazingly complex circuits with tools that can monitor neural activity or recreate it in a natural or biomimetic way. We’ve developed expertise in MEMS and microsystem technology because we believe it offers novel ways to combine optical stimulation, recording arrays, drug delivery, biocompatible and flexible materials, and novel packaging solutions. ​

In-vitro platform for artificial neural circuit

3D in vitro neural culture systems have received great attention to mimic neural circuits; co-culturing different kinds of neurons from various brain regions in a single chip will enable more effective screening of drugs for brain diseases and modulating the neural circuits in vitro.

We design 3D multi-functional neural probe array integrated with optical, chemical, and electrical stimulation capabilities, developed for mapping the 3D functional connectivity among neurons cultured in a 3D hydrogel neuron chip. It can stimulate neurons with various modalities and track the propagated neural activities in the whole 3D hydrogel chip using the 3D electrode array.

Miniaturized Fluorescence Imaging System

Fluorescent microscopy is a powerful tool for monitoring cell dynamics and analyzing fluorescent molecular in biology. Lensless fluorescent microscopy has been developed and it offers advantages regarding cost, portability, and a wide field of view.

We develop a high-resolution lensless fluorescence imaging system using membrane deflection for reducing the gap between fluorescent samples and a CMOS image sensor array. The presented system applied the principle of the total internal reflection of excitation light inside a PDMS chip to minimize the exposure of excitation light to the image sensor.

International Journal
  • [49] Y Shin, YK Kim, SK Lee, H Shin, IJ Cho, JH Park (2019), Microprobe electrode array with individual interconnects through substrate using silicon through-glass via, Sensors and Actuators B: Chemical 290, 336-346
  • [48] SJ Jeong, IY Lee, BO Jun, YJ Ryu, J Sohn, SP Kim, CW Woo, JW Koo, … (2019), Korea Brain Initiative: Emerging Issues and Institutionalization of Neuroethics, Neuron 101 (3), 390-393
  • [47] JR Ryu, JH Kim, HM Cho, Y Jo, B Lee, S Joo, U Chae, Y Nam, IJ Cho, … (2019), A monitoring system for axonal growth dynamics using micropatterns of permissive and Semaphorin 3F chemorepulsive signals, Lab on a Chip 19 (2), 291-305
  • [46] J Choi, M Jeun, SS Yuk, S Park, J Choi, D Lee, H Shin, H Kim, IJ Cho, … (2018), Fully Packaged Portable Thin Film Biosensor for the Direct Detection of Highly Pathogenic Viruses from On-Site Samples, ACS nano 13 (1), 812-820
  • [45] D Roh, W Choi, J Kim, HY Yu, N Choi, IJ Cho (2018), Fabrication of Multi-layered Macroscopic Hydrogel Scaffold Composed of Multiple Components by Precise Control of UV Energy, BioChip Journal 12 (4), 280-286
  • [44] G Kook, S Jeong, SH Kim, MK Kim, S Lee, IJ Cho, N Choi, HJ Lee (2018), Wafer-Scale Multilayer Fabrication for Silk Fibroin-Based Microelectronics, ACS applied materials & interfaces 11 (1), 115-124
  • [43] S Lim, D Kim, S Ju, S Shin, I Cho, SH Park, R Grailhe, C Lee, YK Kim (2018), Glioblastoma-secreted soluble CD44 activates tau pathology in the brain, Experimental & molecular medicine 50 (4), 5
  • [42] HJ Lee, N Choi, ES Yoon, IJ Cho (2017), MEMS devices for drug delivery, Advanced drug delivery reviews 128, 132-147
  • [41] Pendyala, P., Kim, H. N., Grewal, H. S., Cho, I. J., & Yoon, E. S. (2017). Effect of capillary forces on the correlation 
between nanoscale adhesion and friction of polymer patterned surfaces. Tribology International, 114, 436-444.
  • [40] Choi, W., Yeom, S. Y., Kim, J., Jung, S., Jung, S., Shim, T. S., Cho, I. J., & Choi, J. (2017). Hydrogel micropost-based 
qPCR for multiplex detection of miRNAs associated with Alzheimer’s disease. Biosensors and Bioelectronics.
  • [39] Lee, J. H., Cho, I. J., Ko, K., Yoon, E. S., Park, H. H., & Kim, T. S. (2017). Flexible piezoelectric micromachined 
ultrasonic transducer (pMUT) for application in brain stimulation. Microsystem Technologies, 23(7), 2321-2328.
  • [38] Cho, I. J., Lee, H. K., Chang, S. I., & Yoon, E. (2017). Compliant Ultrasound Proximity Sensor for the Safe Operation of Human Friendly Robots Integrated with Tactile Sensing Capability. Journal of Electrical Engineering & 
Technology, 12(1), 310-316.
  • [37] Kim, E., Lim, K., Lee, T., Ha, K. S., Han, D. Y., Nam, J., Cho, I. J. & Choi, J. (2016). Mono-dispersed DDR zeolite 
particles by seeded growth and their CO 2, N 2, and H 2 O adsorption properties. Chemical Engineering Journal, 
306, 876-888.
  • [36] Pendyala, P., Grewal, H. S., Kim, H. N., Cho, I. J., & Yoon, E. S. (2016). Individual role of the physicochemical 
characteristics of nanopatterns on tribological surfaces. ACS Applied Materials & Interfaces, 8(44), 30590-30600.
  • [35] Kook, G., Lee, S. W., Lee, H. C., Cho, I. J., & Lee, H. J. (2016). Neural probes for chronic applications. 
Micromachines, 7(10), 179.
  • [34] Son, C., Ko, K., Lee, H. J., Na, K., Han, J., Yun, K. S., & Cho, I. J. (2016). A flexible multimodal tactile display array 
for virtual shape and texture. Microsystem Technologies, 22(10), 2587-2594.
  • [33] Roh, Y. H., Sim, S. J., Cho, I. J., Choi, N., & Bong, K. W. (2016). Vertically encoded tetragonal hydrogel 
microparticles for multiplexed detection of miRNAs associated with Alzheimer’s disease. Analyst, 141(15), 4578- 4586.
  • [32] Grewal, H. S., Piao, S., Cho, I. J., Jhang, K. Y., & Yoon, E. S. (2016). Nanotribological and wetting performance of 
hierarchical patterns. Soft matter, 12(3), 859-866.
  • [31] Yeom, S. Y., Son, C. H., Kim, B. S., Tag, S. H., Nam, E., Shin, H., Im, H. I.*, Cho I. J.* Choi, N. W.* (2016). 
“Multiplexed Detection of Epigenetic Markers Using Quantum Dot (QD)-Encoded Hydrogel Microparticles.” 
Analytical Chemistry. (Co-corresponding)
  • [30] Some S., Sohn J. S., Kim J., Lee S. H. Lee S. C., Lee J., Kim S. H., Choi N., Cho, I. J., Jun S. C. (2016). “Graphene- 
Iodine Nano composites: Highly Potent Bacterial Inhibitors that are Bio-compatible with Human Cells”, Scientific 
reports, accepted for publication.
  • [29] Hwang, D. G., Chae, Y. M., Choi, N., Cho, I. J., Kang, J. Y., & Lee, S. H. (2016). “Label-free detection of prostate 
specific antigen (PSA) using a bridge-shaped PZT resonator.” Microsystem Technologies, 1-8. Online published
  • [28] Gallo, S., Son, C., Lee, H. J., Bleuler, H., & Cho, I. J. (2015). A flexible multimodal tactile display for delivering shape 
and material information. Sensors and Actuators A: Physical, 236, 180-189.
  • [27] Grewal, H. S., Piao, S., Cho, I. J., Jhang, K. Y., & Yoon, E. S. (2016). Nanotribological and wetting performance of 
hierarchical patterns. Soft matter.
  • [26] Yu, S., Kim, D., Cho, I. J., & Yun, K. S. (2015). “Optimization of ferrofluid motion on solid substrate and its 
application to micro-mirror device.” Japanese Journal of Applied Physics, 54(6S1), 06FP02.
  • [25] Grewal, H. S., Cho, I. J., & Yoon, E. S. (2015). “The role of bio-inspired hierarchical structures in wetting.” 
Bioinspiration & biomimetics, 10(2), 026009.
  • [24] Shin, H., Lee, H. J., Chae, U., Kim, H., Kim, J., Choi, N., … & Cho, I. J. (2015). “Neural probes with multi-drug 
delivery capability.” Lab on a Chip, 15(18), 3730-3737.
  • [23] Lee, H. J., Son, Y., Kim, J., Lee, C. J., Yoon, E. S., & Cho, I. J. (2015). “A multichannel neural probe with embedded 
microfluidic channels for simultaneous in vivo neural recording and drug delivery.” Lab on a Chip, 15(6), 1590-
  • [22] Son, Y., Lee, H. J., Kim, J., Shin, H., Choi, N., Lee, C. J., … & Cho, I. J. (2015). “In vivo optical modulation of neural 
signals using monolithically integrated two-dimensional neural probe arrays.” Scientific reports, 5.
  • [21] Cho, I. H., Shin, H., Lee, H. J., & Cho, I. J. (2015) “Effects of Fabrication Process Variation on Impedance of Neural 
Probe Microelectrodes.” Elect. Eng. Technol. vol. 10, 30-35
  • [20] Lee,H. J., Son, Y., Kim, D., Kim, Y. K., Choi, N., Yoon, E. S., &Cho, I. J. “A new thin silicon microneedle with an 
embedded microchannel for deep brain drug infusion.” Sensors and Actuators B: Chemical, 2015.
  • [19] Lee,S. M., Nguyen, T. H., Na, K., Cho, I. J., Woo, D. H., Oh, J. E., &Yoon, E.S. “Nanomechanical measurement of 
astrocyte stiffncess correlated with cytoskeletal maturation.” Journal of Biomedical Materials Research Part A, 2014.
  • [18] Grewal,H. S., Cho, I. J., Oh, J. E., &Yoon, E. S. “Effect of topography on the wetting of nanoscale patterns: 
experimental and modeling studies.” Nanoscale, 6(24), 15321-15332, 2014.
  • [17] Jeon,M., Cho, J., Kim, Y. K., Jung, D., Yoon, E. S., Shin, S., &Cho, I. J. “Partially flexible MEMS neural probe 
composed of polyimide and sucrose gel for reducingbrain damage during and after implantation.” Journal of 
Micromechanics and Microengineering, 24(2), 025010, 2014.
  • [16] Lee,H. J., Kim, Y., Yoon, E. S., &Cho, I. J. “Versatile Size and ShapeMicrolens Arrays With High Numerical Apertures” 
JMEMS Letters, 2014.
  • [15] Wu,F., Stark, E., Im, M., Cho, I. J., Yoon, E. S., Buzsá ki, G., &Yoon, E. “An implantable neural probe with 
monolithically integrated dielectric waveguide and recording electrodes for optogenetics applications.” Journal of 
neural engineering, 10(5), 056012, 2013.
  • [14] Il-Joo Cho, Kwang-Seok Yoon and Hyo-Jin Nam, “A High-Speed Single Crystal Silicon AFM Probe Integrated with 
PZT Actuator for High-Speed Imaging Applications”, Journal of Electrical Engineering & Technology, vol.6, no.1, 2011
  • [13] Pham Due Cuong, Kyungwhan Na, Suhak Park, Il-Joo Cho, Kyungyoung Chang and Eui-Sung Yoon,” Wetting 
behavior and nanotribological properties of silicon nanopatterns combined with diamond-like carbon and 
perfluoropolyether films”, Nanotechnology, vol. 22, no.39, 2011
  • [12] Il-Joo Cho and Euisik Yoon, “Design and Fabrication of a Single Membrane Push-Pull SPDT RF MEMS Switch 
Operated by Electromagnetic Actuation and Electrostatic Hold”, Journal of Micromechanics and Microengineering, 
 20, 035028, March 2010.
  • [11] Il-Joo cho and Euisik Yoon, “A Low-Voltage Three-Axis Electromagnetically Actuated Micromirror for Fine 
Alignment Among Optical Devices”, Journal of Micromechanics and Microengineering, vol. 29, 085007, July 2009.
  • [10] Il-Joo Cho, Seongsoo Jang and Hyo-Jin Nam, “A Piezoelectrically Actuated MEMS Speaker with Polyimide 
Membrane and Thin film Pb(Zr,Ti)O3(PZT) Actuator,” Integrated Ferroelectrics, vol. 105, pp. 27-36, August 2009.
  • [9] Caroline Sunyong Lee, Hyo-Jin Nam, Sung-Soo Jang, Il-Joo Cho and Jong-Uk Bu, “Investigation on PZT Damage 
During Wafer-Level Bonding of Thermo-Piezoelectric Cantilevers with CMOS Wafers for Probe-Based Data Storage”, 
JKPS, Vol. 51, No.4, pp. 1374~1377, October 2007.
  • [8] Maesoon Im, Il-Joo Cho, Kwang-Seok Yun and Euisik Yoon, “Electromagnetic Actuation and Microchannel 
Engineering of a Polymer Micropen Array Integrated with Microchannels and Sample Reservoirs for Biological 
Assay Patterning,” Applied Physics Letters, Vol.91, No.12, pp.124101-1-124101-3, September 2007.
  • [7] Caroline Sun-Yong Lee, Sung-Geun Kim, Suk-Yong Jeong, Sung-Hoon Ahn, Won-Hyeog Jin, Sung-Soo Jang, Il-Joo Cho, Young-Sik Kim and Hyo-Jin Nam , “Thermal Analysis of Micro Cantilevers Integrated with Heaters for Low Power Nano-Data-Storage Application” Sensors and Actuators A: Physical, Volume 139, Issues 1-2, pp.12-16, 
September 2007.
  • [6] Young-Sik Kim, Seongsoo Jang, Caroline Sunyong Lee, Won-Hyeog Jin, II-Joo Cho, Man-Hyo Ha, Hyo-Jin Nam, 
Jong-Uk Bu, Sun-II Chang and Euisik Yoon “Thermo-Piezoelectric Si3N4 Cantilever Array on CMOS Circuit for High Density Probe-Based Data Storage,” Sensors and Actuators A: Physical, Volume 135, Issue 1, pp. 67-72, March 2007.
  • [5] Hyo-Jin Nam, Young-Sik Kim, Caroline Sunyong Lee, Won-Hyeog Jin, Seong-Soo Jang, Il-Joo Cho, Jong-Uk Bu, Woo Beom Choi and Seung Woo Choi, “Silicon Nitride Cantilever Array Integrated with Silicon Heaters and Piezoelectric Detectors for Probe-Based Data Storage,” Sensors and Actuators A: Physical, Volume 134, Issue 2, pp 329-333, March 2007.
  • [4] Il-Joo Cho, Taeksang Song, Sang-Hyun Baek and Euisik Yoon, “A Low-Voltage and Low-Power RF MEMS Series and Shunt Switches Actuated by Combination of Electromagnetic and Electrostatic Forces”, IEEE Transactions on Microwave Theory and Techniques, Vol., 53, No.7, July 2005.
  • [3] Kwang-Seok Yun, Il-Joo Cho, Jong-Uk Bu, Chang-Jin Kim and Euisik Yoon, “A Surface Tension Driven Micropump for Low-Voltage and Low-Power Operations,” Journal of Microelectromechanical Systems, Vol. 11, Issue 5, pp. 454-461, October 2002.
  • [2] Kwang-Hyun Lee, Hyung-Kew Lee, Hee-Jin Byun, Il-Joo Cho, Jong-Uk Bu and Euisik Yoon, “An Audio Frequency Filter Application of Micromachined Thermally-Isolated Diaphragm Structures,” Sensors and Actuators A: Physical, vol. 89, pp.49-55, March 2001.
  • [1]  Il-Joo Cho, Eun-Chul Park, Songcheol Hong, Euisik Yoon, “Atomic Force Microscope Probe Tips Using Heavily Boron-Doped Silicon Cantilevers Realized in a <110> Bulk Silicon Wafer,” Japanese Journal of Applied Physics ­ Part 1:Regular Papers and Short Notes, Vol. 39, No. 12B, pp. 7103-7179, December 2000.

KMEMS 2016 학회 참석

Joint LAB M.T. (2017)

Nick's farewell lunch

Nick’s farewell lunch (2018.7)

2019 KMEMS 학회 (2019.4.4~4.6)

전체 2
번호 제목 작성자 작성일 추천 조회
공지사항
테스트 공지사항 입니다.
kist | 2018.06.15 | 추천 0 | 조회 359
kist 2018.06.15 0 359
1
TEST
kist | 2018.08.06 | 추천 0 | 조회 343
kist 2018.08.06 0 343